Gene Information
NCBI Gene ID 817722
Symbol SAD2
LocusTag AT2G31660
Synonyms SUPER SENSITIVE TO ABA AND DROUGHT2|T9H9.18|T9H9_18
Description SAD2 (SUPER SENSITIVE TO ABA AND DROUGHT2); protein transporter
Gene Type protein-coding
Pattern SAD2|AT2G31660|SUPER SENSITIVE TO ABA AND DROUGHT2|T9H9.18|T9H9_18|SAD2 (SUPER SENSITIVE TO ABA AND DROUGHT2); protein transporter
Corresponding sequence in Trichome EST library AL379134 AM783142 BI271147 BI934251 BI934527 BQ138572 EB678689 EY037258 EY037259 EY088516 EY102174 EY103174 EY103175 EY116007 EY116008 FG145556 FG198448 FS413047 TCHL53523 TCHL53524 TCHL56991 

Reference

SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression.
Gao Y, Gong X, Cao W, Zhao J, Fu L, Wang X, Schumaker KS, Guo Y. J Integr Plant Biol. 2008 Jul;50(7):906-17

...... or regulatory components in transcriptional networks and include GLABROUS1 (GL1), GLABRA2 (GL2), GLABRA3 (GL3) and TRANSPARENT TESTA GLABRA1 (TTG1). Herein, we report that an importin beta-like protein, SENSITIVE TO ABA AND DROUGHT2 (SAD2), is required for trichome initiation. Mutations in SAD2 disrupted trichome initiation resulting in reduced trichome number, but had no effect on trichome development or root hair number and development. Expression levels of GL1, MYB23, ......


...... mutants while expression levels of GL3 and ENHANCER OF GLABRA3 (EGL3) were enhanced. Overexpression of GL3 increased trichome numbers in wild type but not in sad2 mutants, indicating that the function of the GL3 protein is altered in the sad2 mutants. In contrast, overexpression of GFP-GL1 decreased trichome number in both wild type and sad2. Double mutant analysis of gl1 sad2 and gl3 sad2 indicated that SAD2 functions genetically, at least in part, in the same pathway with ......


...... two genes. Co-immunoprecipitation indicated that the sad2 mutation does not disrupt formation of the TTG1-GL3-GL1 complex. Analysis of GFP fusions of GL1, GL2, GL3 and TTG1 suggested that these proteins are most likely not direct cargo of SAD2. Our data suggest that SAD2 is involved in trichome initiation by regulating these nuclear genes. ......