| Gene Information | |
| NCBI Gene ID | 831001 |
| Symbol | CYC3B |
| LocusTag | AT5G11300 |
| Synonyms | CYC2BAT|CYCA2;2|CYCLIN|CYCLIN A2;2|MITOTIC-LIKE CYCLIN 3B FROM ARABIDOPSIS |
| Description | CYC3B (MITOTIC-LIKE CYCLIN 3B FROM ARABIDOPSIS); cyclin-dependent protein kinase regulator |
| Gene Type | protein-coding |
| Pattern | CYC3B|AT5G11300|CYC2BAT|CYCA2;2|CYCLIN|CYCLIN A2;2|MITOTIC-LIKE CYCLIN 3B FROM ARABIDOPSIS|CYC3B (MITOTIC-LIKE CYCLIN 3B FROM ARABIDOPSIS); cyclin-dependent protein kinase regulator |
| Corresponding sequence in Trichome EST library | AW776255 BE462393 BQ255253 EH371373 EX529134 EY088203 FG621503 GO601036 HO845685 TCMT49293 TOBNTCYCB |
| Reference |
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Genetic interaction between glabra3-shapeshifter and siamese in Arabidopsis thaliana converts trichome precursors into cells with meristematic activity. Marks MD, Gilding E, Wenger JP. Plant J. 2007 Oct;52(2):352-61. ...... gene expression compared with wild type during gl3-sst mutant trichome development. The other mutant allele, sim, is a likely loss of function allele derived from the SIM locus, which is predicted to encode a negative regulator of D-type cyclin activity. The gl3-sst sim double mutant exhibits mounds of cells derived from the proliferation of single trichome precursors. The ectopic expression of a D-type cyclin gene in gl3-sst mimics the double mutant phenotype. Thus, an ...... |
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SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Churchman ML, Brown ML, Kato N, Kirik V, Hülskamp M, Inzé D, De Veylder L,Walker JD, Zheng Z, Oppenheimer DG, Gwin T, Churchman J, Larkin JC. Plant Cell. 2006 Nov;18(11):3145-57. ...... of approximately 16C to 32C. These observations suggested that SIM is required to suppress mitosis as part of the switch to endoreplication in trichomes. Here, we demonstrate that SIM encodes a nuclear-localized 14-kD protein containing a cyclin binding motif and a motif found in ICK/KRP (for Interactors of Cdc2 kinase/Kip-related protein) cell cycle inhibitor proteins. Accordingly, SIM was found to associate with D-type cyclins and CDKA;1. Homologs of SIM were detected in other ...... |
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The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication. Imai KK, Ohashi Y, Tsuge T, Yoshizumi T, Matsui M, Oka A, Aoyama T. Plant Cell. 2006 Feb;18(2):382-96. ...... cyclin A gene, CYCA2;3, was revealed to be active in developing trichomes during the termination period of endoreduplication as well as in proliferating tissues. Taking advantage of the situation that plants encode highly redundant cyclin A genes, we were able to perform functional dissection of CYCA2;3 using null mutant alleles. Null mutations of CYCA2;3 semidominantly promoted endocycles and increased the ploidy levels achieved in mature organs, but they did not ...... |
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Ectopic D-type cyclin expression induces not only DNA replication but also cell division in Arabidopsis trichomes. Schnittger A, Schobinger U, Bouyer D, Weinl C, Stierhof YD, Hulskamp M. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6410-5. ...... how they are linked in higher eukaryotes. In animals, D-type cyclins have been implicated in the control of cell-cycle progression in mitotic as well as in endoreduplicating cells. By contrast, we show that the expression of the D-type cyclin CYCD3;1 in endoreduplicating Arabidopsis trichome cells not only induced DNA replication but also cell divisions. ...... |
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Ectopic B-type cyclin expression induces mitotic cycles in endoreduplicating Arabidopsis trichomes. Schnittger A, Schobinger U, Stierhof YD, Hulskamp M. Curr Biol. 2002 Mar 5;12(5):415-20. ...... transition is negatively regulated. It is unknown how the mitotic factors are repressed and what the functional significance of their suppression is. To test the function of two mitotic cyclins in an endoreduplication cycle, we expressed CYCLIN B1;1 and CYCLIN B1;2 in unicellular Arabidopsis trichomes. During wild-type development, trichomes undergo an average of four endoreduplication cycles, leading to a DNA content of approximately 32C. We find that ectopic expression of ...... |
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...... B1;2, not CYCLIN B1;1, induces mitotic divisions resulting in multicellular trichomes. The CYCLIN B1;2-triggered cell divisions appeared normal with respect to both nuclear division and cytokinesis. We show that CYCLIN B1;2 is misexpressed in the siamese mutant, which also produces multicellular trichomes. Additional overexpression of CYCLIN B1;2 in a siamese mutant background caused a strongly enhanced phenotype. ...... |