The Arabidopsis SPIKE1 gene is required for normal cell shape control and tissue development. Qiu JL, Jilk R, Marks MD, Szymanski DB. Plant Cell. 2002 Jan;14(1):101-18.
...... of the distinct requirements for microtubules and actin filaments during leaf trichome development, a trichome-based morphology screen is an efficient approach to identify genes that affect cytoplasmic organization. The seedling lethal spike1 mutant was identified based on trichome, cotyledon, and leaf-shape defects. The predicted SPIKE1 protein shares amino acid identity with a large family of adapter proteins present in humans, flies, and worms that integrate extracellular ......
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